In addition, miR-15b has been recently proposed as potential biomarker for colorectal cancer since it has been found upregulated in colorectal cancer patients, which suggests a relevant role of this miRNA in the progression of the disease. The determination of the circulating miRNAs is a non-invasive and relatively accessible method which could be useful in order to discriminate the responder and non-responder individuals during the treatment. Future work should be directed both to analyze the functional role of these molecules in the action of this agent, and to investigate their clinical value as potential molecular biomarkers. Acute coronary syndromes are a major cause of death worldwide. In emergency rooms, patients with chest pain and symptoms suggestive of ACS account for a large part of medical admissions. However, a wide spectrum of clinical presentations may be associated with cardiac ischemia. Hence, in these patients, rapid identification, risk stratification, and appropriate selection for early percutaneous coronary revascularization or coronary artery bypass grafting are crucial for prognosis. Recently, testing for high-sensitive cardiac troponin has been shown to be even more sensitive compared to conventional assays. However, designed to improve the detection of minimal myocardial injury and to minimize the number of unidentified ACS patients, high-sensitive assays show decreased specificity. Indeed, various cardiac and non-cardiac conditions including tachyarrhythmias, hypertensive episodes, congestive heart failure, pulmonary embolism, sepsis, and high intensity training have been associated with a rise in hs-cTnT. Thus, despite the ability of clearly ruling-out the likelihood of ACS in patients with chest pain, the increased number of individuals testing positive for troponin has hampered decision making in daily clinical practice. Particularly, the decision when to perform coronary angiography in individuals without obvious STsegment elevations remains challenging and calls for complementary rule-in parameters to identify those at particular risk of impending cardiac events. Accordingly, for the purpose of this study, CE comprise not only the conventional endpoints of subsequent myocardial infarction and cardiovascular death, but, by operational definition, also the need for coronary revascularization established by means of coronary angiography. Besides sensitive indicators of myocardial injury such as hearttype fatty acid-binding protein, markers of coronary plaque activation and/or instability appear most promising in such context. Several groups, including our own, have recently suggested myeloid-related protein 8/14, a marker of phagocyte activation highly expressed in coronary thrombi as a candidate marker for the early detection of atherothrombosis and ACS. Early indicators of coronary plaque instability also include pregnancy-associated plasma protein A.