Indeed, the different correlations among parameters that we obtained could be also explained by the fact that, at present time, CSC’s markers are specific for the stemness characteristic. Since the identification and characterization of CSC markers is difficult, CSC marker Evofosfamide 918633-87-1 cocktails might be more representative of the cancer stem cell biological properties. From our investigations, different linear correlations among parameters have been discovered when different markers have been considered to infer subpopulation proportions. In detail, as summarized in Table 2, it is interesting to note that dependencies involving PC variations are mainly associated with Sca-1 experiments, while correlations on CSC variations have been found considering CD44 + /CD242 cells. All dynamics considered in our model are related to how cell population vary and cancer progression has been connected to crucial cellular events, as CSC proliferation. Obviously, a deeper characterization of specific cellular events during tumor progression might require the integration of molecular aspects in model. However, we believe that results presented in this paper can be used to facilitate and improve this integration. Hence, in a future work we will combine these results with those of our recent paper, in which ErbB2-driven carcinogenesis is described with a multi-level model based on both molecular aspects and cell subpopulation dynamics. Environmental stressors, such as contaminants, prey availability, and adverse weather, can elicit strong physiological responses from wild birds in order to help them overcome short-term challenges. These responses can be particularly harmful during the early stages of life if the response exceeds physiological norms. Physiological and behavioral responses can manifest throughout the annual cycle by many avian species in order to cope with seasonal environmental stochasticity. Understanding avian responses to multiple environmental stressors, when one of those stressors is an environmental contaminant, is poorly understood, yet this situation is prevalent in many anthropogenically-impacted environments. Mercury contamination and subsequent bioaccumulation in waterbirds is problematic in wetlands throughout the world. Inorganic Hg is converted into the toxic and bioaccumulative form methylmercury under biogeochemical conditions that are common in wetland ecosystems. Once methylated, MeHg biomagnifies as it is transferred through the food chain. Environmentally relevant Hg concentrations in birds have been associated with a suite of impaired physiological and reproductive responses, including altered reproductive hormone levels, compromised hypothalamic-pituitary-adrenal axis, and reduced reproductive performance. The decline of several species of Everglades’ wading bird between the 1930s and 2001 has been related to changes in prey availability and alterations to the ecosystem’s hydrology and possibly due to Hg exposure. Great egrets and white ibis are two of the most common breeding waterbirds in the Everglades, and they exhibit different foraging strategies that influence their exposure to ecological stressors.