Natural fruits, nuts, herbs and vegetables constitute a wide array of biologically active compounds including ferulic acid, anthocyanins, ellagic acid, punicagins, flavonols, phenolic acids and very important micronutrients such as phosphorus, iron, potassium and calcium, that are found abundantly in the plant kingdom. They are gaining interest due to their beneficial properties and with minimum side effects. Some of these natural products are effective in treating or preventing the majority of cardiovascular, metabolic and neurodegenerative diseases. Antioxidant activity is the key factor of all flavonoids by which they mediate the beneficial effects against the majority of many different diseases. The actions of dietary flavonoids involve a number of effects within the brain, such as modulation of neuronal signaling and the protection against neuronal losses. An extensive study on structure-function relationships of flavonoid activities provides valuable information for rationale drug designs of future pharmaceuticals in the prevention and treatment of several life-threatening diseases. In conclusion, the pomegranates, figs, and date palm fruits grown in Oman provide possible protection against the inflammation in Tg2576 AD mouse brain and the mechanisms of protection may be related to their antioxidant activities of phenolic constituents. Based on the in vivo experimental studies and the active ingredient profiles, it can be concluded that these fruits showed promising therapeutic potential against neurodegenerative diseases including AD, that areassociated with elevated inflammation. However, these results warrant Dabrafenib inquirer further investigation of the mechanisms by which anti-inflammatory properties of these fruits can exert such beneficial effects on the brain in AD-like models. The rapid development of HDAC inhibitors as KRX-0401 Akt inhibitor cancer therapeutics has been fervently applied in more than 80 clinical trials. Understanding the detailed molecular mechanisms of how HDACI mediates anti-cancer activity is necessary in order to successfully facilitate its clinical translation. It suppresses cancer cell survival through various mechanisms, including blocking angiogenesis, inhibiting intracellular stress response pathways, increasing the generation of reactive oxygen species, and influencing endoplasmic reticulum stress response due to impaired handling of mis-folded proteins. Among these anti-cancer activities, HDACI-mediated G1 cell cycle arrest causes an increase in expression of the tumor suppressor gene p21 in a transcription-dependent manner.