Our results were based solely on transcriptomics techniques, however, we believe further studies utilizing techniques such as metabolomics and mineralization studies will reveal more about the adaptive techniques of the strain. In strong aerobic conditions, especially during vigorous metabolic activities, the activities of numerous genes in the respiratory pathway including complexes I, III, IV and V have been reported to be upregulated,Ribocil-C as aerobic organisms will preferably opt for respiratory pathways with greater energy production output. This may be the reason why the glucose fed cells did not display high levels of expression of the complex 2 genes. Finally, as a support to our observed results of uprgeulated type-1 NADH dehydrogenase genes, upregulated activity of formate dehydrogenase genes were also observed in both gene expression results. Formate dehydrogenase functions in anaerobic nitrate respiration by forming a complex with lipid soluble quinone. Nitrate and nitrite reductase genes are known to function in bacterial anaerobic respiration. Although the nitrate reductase genes were not significantly upregulated in our study, nitrite reductase was upregulated. The upregulated expression of these genes may be as a result of formate produced from aromatic substrate metabolism rather than by fermentation as reported by Ferry and Wolfe. Since pyrene was degraded aerobically with Neoseptin-3 the metabolites and respective gene products confirmed in previous studies, the microaerophilic condition in the pyrene-induced bacterial cells might have been a result of oxygenase activities. Numerous monoand dioxygenases are very active during the degradation of aromatic compounds ; and these oxidoreductases incorporate oxygen atoms from molecular oxygen into their substrates. These important enzymes cleave the ultra-stable aromatic ring structures in the notoriously hard-to-degrade polycyclic aromatic hydrocarbon pollutants in the environment. Gout is a common disease resulting from urate crystal deposition in joints, connective tissues, and parenchymal organs including the kidneys, which may present clinically as gouty arthropathy, accumulation of urate crystals in the form of tophaceous deposits in numerous tissues, gouty nephropathy, or uric acid nephrolithiasis.