Unadjusted and adjusted associations of accumulation of SEP with D-dimer were estimated by using simple and multiple regression analysis. The collinearity between variables was checked by the variance inflation factors which was under the reasonable limits indicating that collinearity was not an issue. The multivariate analyses included respondents with complete data on all variables. Our results indicate that there are social differences in the level of D-dimer, such that increased exposure to adverse SEP across the lifecourse is associated with elevated levels of D-dimer in the mid- life. However, these associations were largely,BKM120 explained by CRP, fibrinogen and vWF and other traditional CHD risk factors. We found that socioeconomic circumstances across the lifecourse also contribute independently to raised levels of D-dimer in middle age among women but not in men. The magnitude of the difference in D-dimer levels between the most advantaged and most disadvantaged groups was substantial and accord with a potential role for D-dimer in the pathways that mediate increased cardiovascular risk in disadvantaged social groups. One possible explanation might be that as D-dimer reflects fibrinogen levels as it is a measure of fibrin turnover and it has been shown that fibrinogen levels were raised among those in lower concurrently assessed measures of social BMN673 position. We are in line with other studies that report the positive and significant correlations between D-dimer and fibrinogen. However, our findings are not driven by this correlation suggesting that inflammatory processes account for much the pro-coagulant state in those with disadvantaged social position assuming there are no measurement issues. Additionally we observe positive associations with CRP fibrinogen and vWF which supports our hypothesis that there may be a link between these respective markers of inflammation and D-dimer in middle-aged men and women. A recent study has shown that high levels of education and occupation tended to be associated with lower risks for VTE.