As mitochondrial dysfunction has been reported in metabolic syndrome, the therapeutic effect of CoQ10 appears to be related to the restoration of mitochondrial function, at least in part. All together, CoQ10 may be a good therapeutic option for OA targeting various pathogenetic mechanisms of the disease including inflammation, dysregulated metabolism, oxidative stress, and mitochondrial dysfunction. In conclusion, this is the first study addressing the therapeutic potential of the CoQ10 in the OA animal model. CoQ10 reduced the pain, ameliorated hisotologic score of the paw with arthritis, and diminished oxidative stress in the OA animal model. Considering the bioenergetic, antioxidant and anti-inflammatory property of CoQ10, this may be a promising therapeutic option for OA, a consequence of inflammation and dysregulated metabolism. The positive individual samples from DS 21 clearly indicate she was excreting virus, and with her urine contributing to the positive pooled urine samples, it is probable that DS 21 was the only one individual excreting virus at the time of sampling, translating to an infection/ excretion prevalence of 1.4%. This prevalence estimate should not be over-interpreted – our study was a cross-sectional ��point in time’ survey, and prevalence will likely vary with a range of factors over time, as indicated by the 95% confidence interval. Previous studies have suggested a positive association between pregnancy and henipavirus infection history, and while this individual was a sexually mature female, her pregnancy status was unknown. Collecting urine from individual flying-foxes can be difficult and urine volume can be limited. Using plastic sheeting under roosting bats to facilitate the collection of pooled urine samples is an effective and efficient way to collect urine samples, and an effective way to detect henipaviruses. We contend that the potential for failed detection of positive individual urines as a result of dilution with negative individual urines is negated or minimized by the sensitivity of current PCR techniques. Further, at a population level, collecting pooled urine samples under roosting flying-foxes means that a greater number of individuals are being sampled, increasing the likelihood of detection when infection prevalence is low. The findings also underline the value of the pooled urine sampling methodology as a means of detecting and AbMole Crovatin characterizing bat henipaviruses. The detection in urinary bladder is novel, and may offer a diagnostic option when a urine sample is not present at necropsy, or when the sampling strategy targets wet markets. Virus isolation was not undertaken. Nipah virus is categorized as a BSL 4 agent, and Indonesia does not currently have a laboratory with BSL4 facilities. Realtime PCR and RT- PCR represent a practical and robust alternative to detect Nipah virus from field samples in this situation.