With acute inflammatory responses appearing early and fibrotic responses appearing later with prolonged task performance. However, we have not examined the effects of performing repetitive tasks beyond 12 weeks in this model; this is necessary in order to parse out which mechanism, inflammation or fibrosis, is contributing to persistent motor declines. In this study, we extended our past shorter-term studies of 12 weeks or less, to examine the effects of performing the high repetition low force, handle-pulling, task for 18 to 24 weeks on forearm grip strength, and on inflammatory, fibrotic or degradative responses in forearm muscle and tendons. We hypothesize that acute inflammatory responses contribute to early declines in grip strength and that fibrogenic tissue responses contribute to chronic grip strength declines. We also sought to identify serum biomarkers indicative of underlying tissue processes, hypothesizing that at least one serum biomarker of each process would be detectable in serum. Following this discovery, the baboon quickly gained interest in the scientific community as an experimental animal model for the study of atherosclerosis. During the last 50 years, the baboon has become a well-characterized and validated primate model for many other areas of biomedical research as well, including cholesterol metabolism, hypertension, obesity, diabetes, embryology, endometriosis, epilepsy, osteoporosis, alcoholic liver disease, gastroesophageal reflux disease, and a variety of infectious diseases. Based on the results from this study and the related reports, we propose an integrative model for the presumptive roles played by the representative molecules that distinguish these three rabbit cell types. In this model, the a-tubulin and TCP-1a proteins may play an active role in cell proliferation and/or as regulative proteins for the cytoskeleton in rES cells. Peroxiredoxin 1 functions to serve as a reactive Butenafine hydrochloride oxygen species scavenger or detoxifier to protect cytoplasm from internal and external environmental stresses. It has been suggested that HSP60 is associated with the Atractylenolide-III stemness of ES cells, in which it may bind some pluripotency proteins or genes that are related to stress tolerance and/or maintenance of ES cell pluripotency. In addition, HSP90 hydrolyzes ATP and forms a stable complex with HSP70 and HOP which binds and regulates the activity of chaperones related to the LIF/STAT signaling pathway. In this context, some other key molecules, such as peroxiredoxin 2, cytoplasmic linker 2 and cofilin-1, which are all expressed in rabbit ES cells, may have actively taken part in maintaining normal cellular functions of rES cells. Lung cancer is the leading cause of cancer-related deaths in North America. While there has been a decrease in lung cancer deaths among men due to a reduction in tobacco use over the past 50 years. The 5-year overall survival rate for lung cancer is as low has not significantly improved over the past 30 years. Non-small cell lung cancer is the most commonly diagnosed lung cancer accounting for 85% of annual cases. About NSCLC patients present with early stage I disease and receive surgical intervention. However, more than 20% of these patients relapse within five years. Adjuvant therapy has improved survival of a subset of patients with stage II and III disease.